Endocrine Abstracts

Introduction: Pheochromocytomas are tumors derived from the adrenal-medullary chromaffin cells that normally produce catecholamines. Rarely these tumors are non-secreting. In the assessment of a suspected pheochromocytoma, guidelines recommend dosing urinary or plasma metanephrines.Objective: To evaluate the prevalence of pheochromocytomas biochemically non-secreting and their differences.Methods: We searched all patients with meas...

Introduction: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells, enabling the use of radioactive iodine (RAI) for treatment of metastatic disease. Still, a significant proportion of patients with advanced forms of thyroid cancer (TC) became refractory to RAI therapy. Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to m...